The Study of Pancreatic Stellate Cell in the Mechanism of Pancreatic Fibrosis and Intervention of Salvianolic Acid B 胰腺星状细胞在胰腺纤维化中的作用及丹酚酸B的干预阻断研究
Research on pancreatic stellate cell activation and experimental pancreatic fibrosis 急性胰腺炎大鼠胰腺星形细胞激活与纤维化改变的研究
PANCREATIC SCHISTOSOMIASIS Pancreatic fibrosis Objective: To study the growth and development of embryonic pancreatic anlagen transplantation. 目的:研究胚胎胰组织在同种异体内再生长发育的可能性,并根据不同胎龄、不同移植部位的移植胚胰生长状况,研究大鼠胚胰移植的适合胎龄和移植部位。
Roles of nuclear factor-κ B in the development of rat pancreatic fibrosis mediated by angiotensin II 核因子-κB在血管紧张素II介导的大鼠胰腺纤维化发生中的作用
Conclusions Angiotensin ⅱ is involved in TNBS-induced pancreatic fibrosis probably through AT_1 and AT_2-mediated pathways. 结论血管紧张素II可能通过AT1、AT2介导的途径参与了TNBS诱导的大鼠胰腺组织纤维化形成过程。
Pancreatic fibrosis was induced by injection of 2% TNBS into biliopancreatic duct. 大鼠胰管内逆行注射2%三硝基苯磺酸(TNBS)复制胰腺纤维化模型。
Conclusion High expression of transforming growth factor-β 1 ( TGF-β 1) which caused metabolic disorder of ECM may be closely related to the occurrence and development of pancreatic fibrosis for chronic pancreatitis. 结论转化生长因子(TGF)β1持续性高表达造成的ECM代谢紊乱,可能是导致慢性胰腺炎胰腺纤维化发生、发展的重要因素。
Regulation of Angiotensin ⅱ on Cell Apoptosis during the Development of Rat Pancreatic Fibrosis 血管紧张素Ⅱ对大鼠胰腺纤维化过程中细胞凋亡的调节作用
A mechanism study of sophorcarpidine in treatment of pancreatic fibrosis 苦参碱抗大鼠胰腺纤维化作用及机制研究
Faecal elastase-1 test is superior to faecal lipase test in the assessment of exocrine pancreatic function in cystic fibrosis 粪弹性蛋白酶-1检验对囊性纤维化病胰腺外分泌功能的评估作用优于粪脂肪酶检验
Conclusions Losartan alleviates TNBS-induced pancreatic fibrosis in rats, suggesting that rennin-angiotensin system might be one of the important contributors for formation of pancreatic fibrosis. 结论1型血管紧张素Ⅱ受体拮抗剂对TNBS诱导的大鼠胰腺纤维化形成具有抑制作用,表明肾素血管紧张素系统(RAS)在慢性胰腺炎胰腺纤维化的发生发展过程中起重要的介导调节作用。
Expression of angiotensin II receptors after pancreatic fibrosis in rats 血管紧张素Ⅱ受体在胰腺纤维化大鼠胰腺组织中的表达及其意义
Objective To investigate the expression of angiotensin ⅱ receptors in pancreatic tissue and to clarify their effects on development of pancreatic fibrosis in rats. 目的动态观察血管紧张素II受体在胰腺纤维化大鼠胰腺组织中的表达并探讨其可能意义。
Inhibition of pancreatic fibrosis by angiotensin II type I receptor antagonist in rats 1型血管紧张素Ⅱ受体拮抗剂抑制大鼠胰腺纤维化形成
Objective To clarify the effect of lipid peroxidation on activation of pancreatic stellate cells ( PSC) and its role in the formation of pancreatic fibrosis. 目的研究脂质过氧化对胰腺星状细胞(Pancreaticstellatecells,PSC)活化的影响及其在胰腺纤维化形成中的作用。
Pancreatic fibrosis Objective: To investigate the role of glutamine on apoptosis of pancreatic acinus in SAP rats. 目的:研究谷氨酰胺(Gln)对重症急性胰腺炎(SAP)大鼠胰腺细胞凋亡的影响。
In addition to gland atrophy, the pancreatic histopathologic score has a significant difference in the lesions, fibrosis, inflammation and edema in the Exenatide-treated group compared with the control group. 除腺体萎缩外,艾塞那肽实验组胰腺组织病理学评分在病变范围、纤维化、炎症及水肿方面与空白对照组相比均具有显著性差异。
In conclusion, oxidative stress, activation of PSCs and cytokines are the important mechanisms of pancreatic fibrosis and they interact. 氧化应激、PSCs活化和细胞因子是胰腺纤维化的重要机制,三者之间存在交互作用。
Activated PSCs have been identified as an important cellular source of ECM in pancreatic fibrosis. 活化的PSCs是胰腺纤维化过程中胶原产生的重要来源。
Increasing evidences suggest that oxidative stress and lipid peroxidation have tight relation with pancreatic fibrosis. They not only induce pancreatic cell damage directly, but also can activate PSCs, so promote the fibrotic process. 越来越多的研究显示胰腺纤维化的发生发展与氧化应激、脂质过氧化等有关:氧化应激不仅能够直接导致胰腺细胞损伤,还能激活PSCs,加速纤维化进程。
Recent studies display that oxidative stress, pancreatic stellate cells ( PSCs) and cytokines are involved in the pancreatic fibrosis. 近年来的研究发现氧化应激、胰腺星状细胞(Pancreaticstellatecells,PSCs)及多种细胞因子与胰腺纤维化密切相关。
TGF ‐β 3has anti ‐ fibrotic effect on liver fibrosis and pancreatic fibrosis. 同时,TGF-β3具有抗肝纤维化和胰腺纤化的功能。